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BA English Essay Beautiful Places of Pakistan. BA English Essay (Beautiful Places of Pakistan) 2. The Wonderful Himalayas. 3. The Glittering Glaciers. 4. The Great Lakes. 5. The Dashing Deserts. There is no dearth of physical beauty in essay nig our, Pakistan. Pakistan is absolutely riddled with astoundingly beautiful places. Most of these places are concentrated in the Northern parts of the country where pristine rivers flow, and mountains jut together to form narrow valleys. However, beauty in essay workplace, Pakistan isn#8217;t simply restricted to nig our the Northern areas. There is abundant scenic beauty to be found in other places of the resume writing service anchorage country as well. Mostly, it depends on the taste of the person visiting.
Some people like the pure, unadulterated air of the mountains while others prefer the rich density of sprawling urban areas. Since Pakistan boasts of some of the most stunning mountains ranges in the world, it is pertinent to mention the wonderful Himalayas and Karakoram. They are a world in themselves. Nig Our? Almost cut off from the rest of the country, and accessible only by unpaved roads, and intelligence helicopters, the narrow valleys of the highest peaks of Pakistan are the most beautiful, and most worth-visiting. The people of this region are so isolated and ostracized that they welcome any visitors with open arms. The beauty of the essay nig our places themselves is stunning. Resume Writing Anchorage? It simply blows visitors away, the buzzing vibrancy of the white mountain peaks clashing with the comforting greenery of the valleys. Further down the mountain peaks, toward the lower mountain ranges of the Himalayas, come the hill stations of Murree, Abbottabad, Dir, and Nathiagali. Essay? These are most frequented by tourists from around Pakistan, and abroad, and a major chunk of the revenue of this region comes from tourism.
While some of the valleys of Pakistan may be relatively inaccessible to the common person due to analyst cover letter poor infrastructure, the nig our glaciers of the country are simply unapproachable to people except for those with professional training in rock and service anchorage mountain climbing. Nig Our? Ironically, it is these glittering havens that provide a view of staggering beauty to visitors. The pristine, untouched snow, the jagged rocks, the clear skies create a magical aura around a person, one of the reasons why foreign tourists attempt climbing these glaciers in spite of the mounting security threat in culture, the region. Pakistan has an elaborate river system with multiple rivers flowing through the essay country. However, all of these rivers originate somewhere in romeo by baz luhrmann essays, the mountains, and in most valleys, deep blue lakes have formed that gather the excess water away from the rivers. These lakes include the magnificent Lake Saif-ul-Maluk that is shaped as a cup. It is nig our, immensely beautiful, and anchorage has garnered many international awards for its fabled beauty. Finally, Pakistan also has vast stretches of golden sand dunes, where the population density is low, and vegetation practically nonexistent.
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Science/Ovarian Cancer term paper 5715. Of all gynecologic malignancies, ovarian cancer continues to have the. highest mortality and is the most difficult to diagnose. In the United States. female population, ovarian cancer ranks fifth in absolute mortality among. cancer related deaths (13,000/yr). In most reported cases, ovarian cancer, when first diagnosed is in stages III or IV in about 60 to 70% of patients. which further complicates treatment of the disease (Barber, 3). Early detection in ovarian cancer is hampered by essay the lack of appropriate. tumor markers and essay motivation, clinically, most patients fail to develop significant.
symptoms until they reach advanced stage disease. The characteristics. of ovarian cancer have been studied in primary tumors and in established. ovarian tumor cell lines which provide a reproducible source of essay, tumor material. Among the major clinical problems of ovarian cancer, malignant progression, rapid emergence of drug resistance, and associated cross-resistance remain. unresolved. Ovarian cancer has a high frequency of metastasis yet generally. remains localized within the resume service peritoneal cavity. Tumor development has been. associated with aberrant, dysfunctional expression and/or mutation of.
various genes. This can include oncogene overexpression, amplification or. mutation, aberrant tumor suppressor expression or mutation. Also, subversion. of host antitumor immune responses may play a role in nig our, the pathogenesis of. cancer (Sharp, 77). Ovarian clear cell adenocarcinoma was first described by alternative essays Peham in 1899 as.
hypernephroma of the essay ovary because of its resemblance to renal cell carcinoma. By 1939, Schiller noted a histologic similarity to mesonephric tubules and. classified these tumors as mesonephromas. In 1944, Saphir and analyst cover letter, Lackner described. two cases of hypernephroid carcinoma of the essay ovary and a day math, proposed clear cell adenocarcinoma as an alternative term.
Clear cell tumors of the ovary are now. generally considered to nig our be of mullerian and in the genital tract of mullerian origin. A number of examples of math essay, clear cell adenocarcinoma have been reported to arise. from the epithelium of an essay nig our endometriotic cyst (Yoonessi, 289). Occasionally, a renal. cell carcinoma metastasizes to essay the ovary and may be confused with a primary clear. Ovarian clear cell adenocarcinoma (OCCA) has been recognized as a distinct.
histologic entity in the World Health Organization (WHO) classification of ovarian. tumors since 1973 and is the most lethal ovarian neoplasm with an overall five year. survival of only 34% (Kennedy, 342). Clear cell adenocarcinoma, like most ovarian. cancers, originates from the ovarian epithelium which is a single layer of cells found on. the surface of the essay ovary. Patients with ovarian clear cell adenocarcinoma are typically. above the age of 30 with a median of 54 which is similar to that of ovarian epithelial. cancer in general. OCCA represents approximately 6% of romeo by baz, ovarian cancers and bilateral.
ovarian involvement occurs in less that 50% of patients even in advanced cases. The association of essay nig our, OCCA and endometriosis is resume writing service anchorage, well documented (De La Cuesta, 243). This was confirmed by Kennedy et al who encountered histologic or intraoperative. evidence of endometriosis in 45% of their study patients.
Transformation. from endometriosis to clear cell adenocarcinoma has been previously demonstrated in. sporadic cases but was not observed by Kennedy et al. Hypercalcemia occurs in a. significant percentage of patients with OCCA. Patients with advanced disease are more. typically affected than patients with nonmetastatic disease. Patients with OCCA are also.
more likely to have Stage I disease than are patients with ovarian epithelial cancer in. general (Kennedy, 348). Histologic grade has been useful as an initial prognostic determinant in some studies. of epithelial cancers of the ovary. The grading of ovarian clear cell adenocarcinoma has.
been problematic and nig our, is complicated by the multiplicity of histologic patterns found in. the same tumor. Similar problems have been found in attempted grading of clear cell. adenocarcinoma of the endometrium (Disaia, 176). Despite these problems, tumor. grading has been attempted but has failed to demonstrate prognostic significance. However, collected data suggest that low mitotic activity and a predominance of clear. cells may be favorable histologic features (Piver, 136).
Risk factors for OCCA and ovarian cancer in letter, general are much less clear than for. other genital tumors with general agreement on essay, two risk factors: nulliparity and family. history. There is a higher frequency of resume service anchorage, carcinoma in unmarried women and in married. women with low parity.
Gonadal dysgenesis in children is nig our, associated with a higher risk. of developing ovarian cancer while oral contraceptives are associated with a decreased. risk. Genetic and candidate host genes may be altered in rock, susceptible families. Essay! Among. those currently under investigation is BRCA1 which has been associated with an. increased susceptibility to breast cancer. Approximately 30% of ovarian adenocarcinomas. express high levels of HER-2/neu oncogene which correlates with a poor prognosis.
(Altcheck, 375-376). Mutations in host tumor suppresser gene p53 are found in 50% of. ovarian carcinomas. There also appears to be a racial predilection, as the vast majority. of cases are seen in Caucasians (Yoonessi, 295). Considerable variation exists in the gross appearance of ovarian clear cell. adenocarcinomas and they are generally indistinguishable from resume anchorage, other epithelial ovarian. carcinomas. They could be cystic, solid, soft, or rubbery, and may also contain. hemorrhagic and nig our, mucinous areas (O'Donnell, 250).
Microscopically, clear cell. carcinomas are characterized by the presence of variable proportions of essay, clear and hobnail. cells. The former contain abundant clear cytoplasm with often centrally located nuclei, while the latter show clear or pink cytoplasm and essay, bizarre basal nuclei with atypical. cytoplasmic intraluminal projections.
The cellular arrangement may be tubulo acinar, papillary, or solid, with the great majority displaying a mixture of essay motivation, these patterns. Nig Our! The. hobnail and clear cells predominate with tubular and essay motivation workplace, solid forms, respectively (Barber, Clear cell adenocarcinoma tissue fixed with alcohol shows a high cytoplasmic. glycogen content which can be shown by means of essay nig our, special staining techniques.
Abundant extracellular and rare intracellular neutral mucin mixed with sulfate and. carboxyl group is usually present. Essay Workplace! The clear cells are recognized histochemically and. ultrastructurally (short and blunt microvilli, intercellular tight junctions and essay, desmosomes, free ribosomes, and competitive intelligence cover letter, lamellar endoplasmic reticulum). The ultrastructure of hobnail and.
clear cells resemble those of the similar cells seen in clear cell carcinomas of the. remainder of the female genital tract (O'Brien, 254). A variation in patterns of histology. is seen among these tumors and frequently within the same one. Whether both tubular components with hobnail cells and essay, the solid part with clear cells. are required to establish a diagnosis or the presence of just one of the patterns is.
sufficient has not been clearly established. Fortunately, most tumors exhibit a mixture of. these components. Romeo By Baz Luhrmann! Benign and borderline counterparts of clear cell ovarian. adenocarcinomas are theoretical possibilities. Yoonessi et al reported that nodal. metastases could be found even when the disease appears to be grossly limited to the. pelvis (Yoonessi, 296). Examination of retroperitoneal nodes is essential to nig our allow for. more factual staging and carefully planned adjuvant therapy.
Surgery remains the backbone of resume writing, treatment and essay nig our, generally consists of removal of the. uterus, tubes and ovaries, possible partial omentectomy, and nodal biopsies. The. effectiveness and value of adjuvant radiotherapy and chemotherapy has not been clearly. demonstrated. Therefore, in patients with unilateral encapsulated lesions and. histologically proven uninvolvement of the contralateral ovary, omentum, and biopsied. nodes, a case can be made for (a)no adjuvant therapy after complete surgical removal. and (b) removal of only the diseased ovary in an occasional patient who may be young.
and desirous of preserving her reproductive capacity (Altchek, 97). Service Anchorage! In the more adv- anced stages, removal of the uterus, ovaries, omentum, and essay, as much tumor as possible. followed by pelvic radiotherapy (if residual disease is limited to a day without math essay the pelvis) or. chemotherapy must be considered. The chemotherapeutic regimens generally involve. adriamycin, alkylating agents, and cisPlatinum containing combinations (Barber, 442). OCCA is of epithelial origin and essay nig our, often contains mixtures of other epithelial tumors. such as serous, mucinous, and endometrioid. Clear cell adenocarcinoma is characterized.
by large epithelial cells with abundant cytoplasm. Because these tumors sometimes. occur in association with endometriosis or endometrioid carcinoma of the ovary and. resemble clear cell carcinoma of the endometrium, they are now thought to be of. mullerian duct origin and variants of endometrioid adenocarcinoma. Clear cell tumors of.
the ovary can be predominantly solid or cystic. In the solid neoplasm, the clear cells are. arranged in sheets or tubules. In the cystic form, the neoplastic cells line the spaces. Five-year survival is approximately 50% when these tumors are confined to the ovaries, but these tumors tend to be aggressive and spread beyond the math ovary which tends to make.
5-year survival highly unlikely (Altchek, 416). Some debate continues as to whether clear cell or mesonephroid carcinoma is a. separate clinicopathological entity with its own distinctive biologic behavior and natural. history or a histologic variant of endometrioid carcinoma. In an essay nig our effort to characterize. clear cell adenocarcinoma, Jenison et al compared these tumors to the most common of. the epithelial malignancies, the serous adenocarcinoma (SA). Histologically determined. endometriosis was strikingly more common among patients with OCCA than with SA. Other observations by Jenison et al suggest that the biologic behavior of clear cell. adenocarcinoma differs from that of SA. They found Stage I tumors in 50% of the.
observed patient population as well as a lower incidence of bilaterality in essay motivation workplace, OCCA. (Jenison, 67-69). Additionally, it appears that OCCA is characteristically larger than. SA, possibly explaining the greater frequency of symptoms and signs at presentation. There is controversy regarding talc use causing ovarian cancer. Until recently, most. talc powders were contaminated with asbestos.
Conceptually, talcum powder on the. perineum could reach the ovaries by essay absorption through the cervix or vagina. Since. talcum powders are no longer contaminated with asbestos, the risk is probably no longer. important (Barber, 200). The high fat content of whole milk, butter, and meat products. has been implicated with an increased risk for ovarian cancer in general.
The Centers for Disease Control compared 546 women with ovarian cancer to 4,228. controls and competitive analyst, reported that for women 20 to essay nig our 54 years of age, the use of oral. contraceptives reduced the and juliet luhrmann essays risk of essay, ovarian cancer by 40% and the risk of ovarian cancer. decreased as the math essay duration of oral contraceptive use increased. Even the use of oral. contraceptives for three months decreased the risk. The protective effect of oral. contraceptives is to reduce the relative risk to 0.6 or to essay nig our decrease the incidence of disease.
by 40%. There is a decreased risk as high as 40% for women who have had four or. more children as compared to nulliparous women. There is an a day without math essay increase in the incidence. of ovarian cancer among nulliparous women and a decrease with increasing parity. The. incessant ovulation theory proposes that continuous ovulation causes repeated trauma. to the ovary leading to essay the development of ovarian cancer. Incidentally, having two or. more abortions compared to never having had an abortion decreases one's risk of. developing ovarian cancer by 30% (Coppleson, 25-28).
It is commonly accepted that cancer results from romeo and juliet luhrmann essays, a series of genetic alterations that. disrupt normal cellular growth and differentiation. It has been proposed that genetic. changes causing cancer occur in two categories of normal cellular genes, proto- oncogenes and tumor suppressor genes. Genetic changes in nig our, proto-oncogenes facilitate. the transformation of a normal cell to a malignant cell by and juliet by baz luhrmann production of an altered or. overexpressed gene product. Such genetic changes include mutation, translocation, or.
amplification of proto-oncogenes Tumor suppressor genes are proposed to prevent. cancer. Inactivation or loss of these genes contributes to development of cancer by the. lack of a functional gene product. This may require mutations in essay nig our, both alleles of a tumor. suppressor gene.
These genes function as regulatory inhibitors of alternative rock essays, cell proliferation, such. as a DNA transcription factor, or a cell adhesion molecule. Loss of these functions. could result in abnormal cell division or gene expression, or increased ability of cells in. tissues to detach. Cancer such as OCCA most likely results from the dynamic interaction. of several genetically altered proto-oncogenes and tumor suppressor genes (Piver, 64- Until recently, there was little evidence that the origin of ovarian was genetic. Before. 1970, familial ovarian cancer had been reported in only five families.
A familial cancer. registry was established at nig our Roswell Park Cancer Institute in 1981 to document the. number of cases occurring in the United States and to study the motivation workplace mode of inheritance. If. a genetic autosomal dominant transmission of the disease can be established, counseling. for prophylactic oophorectomy at an appropriate age may lead to a decrease in the death. rate from ovarian cancer in such families. The registry at Roswell Park reported 201 cases of ovarian cancer in 94 families in. 1984.
From 1981 through 1991, 820 families and 2946 cases had been observed. Familial ovarian cancer is not a rare occurrence and essay, may account for 2 to 5% of a day essay, all cases. of ovarian cancer. Three conditions that are associated with familial ovarian cancer are. (1) site specific, the essay most common form, which is restricted to ovarian cancer, and (2) breast/ovarian cancer with clustering of ovarian and breast cases in extended pedigrees. (Altchek, 229-230). Resume Writing Anchorage! One characteristic of inherited ovarian cancer is that it occurs at a. significantly younger age than the non-inherited form. Cytogenetic investigations of sporadic (non-inherited) ovarian tumors have revealed. frequent alterations of chromosomes 1,3,6, and 11. Many proto-oncogenes have been.
mapped to these chromosomes, and essay nig our, deletions of segments of chromosomes (particularly. 3p and 6q) in some tumors is consistent with a role for writing loss of tumor suppressor genes. Recently, a genetic linkage study of familial breast/ovary cancer suggested linkage of. disease susceptibility with the essay nig our RH blood group locus on chromosome 1p. Allele loss involving chromosomes 3p and a day math essay, 6q as well as chromosomes 11p, 13q, and. 17 have been frequently observed in ovarian cancers.
Besides allele loss, point mutations. have been identified in nig our, the tumor suppressor gene p53 located on chromosome17p13. Deletions of chromosome 17q have been reported in workplace, sporadic ovarian tumors suggesting. a general involvement of essay nig our, this region in ovarian tumor biology. Allelic loss of MYB and. ESR genes map on chromosome 6q near the provisional locus for alternative rock essays FUCA2, the essay locus for. a-L-fucosidase in serum. Low activity of a-L-fucosidase in serum is more prevalent in. ovarian cancer patients.
This suggests that deficiency of a-L-fucosidase activity in serum. may be a hereditary condition associated with increased risk for developing ovarian. cancer. This together with cytogenetic data of losses of 6q and the allelic losses at 6q. point to the potential importance of chromosome 6q in hereditary ovarian cancer. Activation of normal proto-oncogenes by by baz luhrmann either mutation, translocation, or gene. amplification to produce altered or overexpressed products is believed to essay nig our play an. important role in rock essays, the development of nig our, ovarian tumors. Activation of several proto- oncogenes (particularly K-RAS, H-RAS, c-MYC, and HER-2/neu) occurs in ovarian. tumors. Intelligence Cover Letter! However, the significance remains to be determined.
It is controversial as to. whether overexpression of the HER-2/neu gene in ovarian cancer is associated with poor. prognosis. Essay! In addition to studying proto-oncogenes in tumors, it may be beneficial to. investigate proto-oncogenes in germ-line DNA from members of families with histories. of ovarian cancer (Barber, 323-324). It is math essay, questionable whether inheritance or rare. alleles of the H-RAS proto-oncogene may be linked to susceptibility to ovarian cancers. Diagnosis and Treatment. The early diagnosis of ovarian cancer is a matter of chance and not a triumph of.
scientific approach. In most cases, the finding of essay, a pelvic mass is the competitive cover only available. method of diagnosis, with the exception of functioning tumors which may manifest. endocrine even with minimal ovarian enlargement. Symptomatology includes vague. abdominal discomfort, dyspepsia, increased flatulence, sense of bloating, particularly. after ingesting food, mild digestive disturbances, and pelvic unrest which may be present. for several months before diagnosis (Sharp, 161-163). There are a great number of imaging techniques that are available. Essay! Ultrasounds, particularly vaginal ultrasound, has increased the rate of pick-up of early lesions, particularly when the color Doppler method is used.
Unfortunately, vaginal sonography. and CA 125 have had an increasing number of false positive examinations. Pelvic. findings are often minimal and rock essays, not helpful in making a diagnosis. However, combined.
with a high index of suspicion, this may alert the physician to the diagnosis. These pelvic signs include: Mass in the ovarian area. Relative immobility due to fixation of nig our, adhesions. Irregularity of the tumor. Shotty consistency with increased firmness.
Tumors in essay, the cul-de-sac described as a handful of knuckles. Relative insensitivity of the mass. Increasing size under observation. Bilaterality (70% for ovarian carcinoma versus 5% for benign cases) (Barber, 136) Tumor markers have been particularly useful in monitoring treatment, however, the. markers have and will probably always have a disadvantage in identifying an nig our early. tumor.
To date, only two, human gonadotropin (HCG) and alpha fetoprotein, are. known to be sensitive and specific. The problem with tumor markers as a means of. making a diagnosis is that a tumor marker is developed from a certain volume of tumor. By that time it is no longer an early but rather a biologically late tumor (Altchek, 292). Many reports have described murine monoclonal antibodies (MAbs) as potential tools. for diagnosing malignant ovarian tumors.
Yamada et al attempted to develop a MAb. that can differentiate cells with early malignant change from adjacent benign tumor cells. in cases of a day without essay, borderline malignancy. They developed MAb 12C3 by immunizing mice with. a cell line derived from a human ovarian tumor. Nig Our! The antibody reacted with human. ovarian carcinomas rather than with germ cell tumors.
MAb 12C3 stained 67.7% of. ovarian epithelial malignancies, but exhibited an extremely low reactivity with other. malignancies. Without! MAb 12C3 detected a novel antigen whose distribution in normal tissue is. restricted. According to Yamada et al, MAb 12C3 will serve as a powerful new tool for. the histologic detection of early malignant changes in borderline epithelial neoplasms. MAb 12C3 may also be useful as a targeting agent for cancer chemotherapy (Yamada, Currently there are several serum markers that are available to help make a diagnosis. These include CA 125, CEA, DNB/70K, LASA-P, and serum inhibin.
Recently the. urinary gonadotropin peptide (UCP) and the collagen-stimulating factor have been. added. Although the nig our tumor markers have a low specificity and sensitivity, they are often. used in screening for ovarian cancer.
A new tumor marker CA125-2 has greater. specificity than CA125. In general, tumor markers have a very limited role in screening. for ovarian cancer. The common epithelial cancer of the ovary is by baz essays, unique in killing the patient while being, in the vast majority of the cases, enclosed in the anatomical area where it initially. developed: the peritoneal cavity. Even with early localized cancer, lymph node. metastases are not rare in essay, the pelvic or aortic areas. In most of the cases, death is due to.
intraperitoneal proliferation, ascites, protein loss and cachexia. The concept of. debulking or cytoreductive surgery is currently the dominant concept in treatment. The first goal in cover letter, debulking surgery is inhibition of debulking surgery is inhibition of. the vicious cycle of malnutrition, nausea, vomiting, and essay nig our, dyspepsia commonly found in. patients with mid to math advanced stage disease.
Cytoreductive surgery enhances the. efficiency of chemotherapy as the survival curve of the essay patients whose largest residual. mass size was, after surgery, below the 1.5 cm limit is the same as the curve of the. patients whose largest metastatic lesions were below the romeo by baz luhrmann 1.5 cm limit at the outset. The aggressiveness of the debulking surgery is a key question surgeons must face. when treating ovarian cancers. The debulking of essay nig our, very large metastatic masses makes no. sense from the oncologic perspective.
As for extrapelvic masses the culture essay debulking, even if. more acceptable, remains full of nig our, danger and exposes the romeo and juliet by baz luhrmann essays patient to a heavy handicap. For these reasons the extra-genital resections have to be limited to lymphadenectomy, omentectomy, pelvic abdominal peritoneal resections and rectosigmoid junction. resection. That means that stages IIB and essay, IIC and stages IIIA and IIB are the only true. indications for culture essay prompts extrapelvic cytoreductive surgery. Colectomy, ileectomy, splenectomy, segmental hepatectomy are only exceptionally indicated if they allow one to perform a. real optimal resection. The standard cytoreductive surgery is the essay total hysterectomy with.
bilateral salpingoophorectomy. Rock Essays! This surgery may be done with aortic and pelvic lymph. node sampling, omentectomy, and, if necessary, resection of the rectosigmoidal junction. The concept of essay nig our, administering drugs directly into alternative rock essays the peritoneal cavity as therapy of. ovarian cancer was attempted more than three decades ago.
However, it has only been. within the last ten years that a firm basis for nig our this method of essay workplace, drug delivery has become. established. The essential goal is to expose the tumor to higher concentrations of drug. for longer periods of essay nig our, time than is possible with systemic drug delivery. Several agents. have been examined for their efficacy, safety and pharmacokinetic advantage when.
administered via the peritoneal route. Cisplatin has undergone the most extensive evaluation for regional delivery. Cisplatin. reaches the systemic compartment in significant concentrations when it is administered. intraperitoneally. Culture Essay! The dose limiting toxicity of intraperitoneally administered cisplatin is. nephrotoxicity, neurotoxicity and emesis. The depth of penetration of cisplatin into the. peritoneal lining and tumor following regional delivery is only 1 to 2 mm from the. surface which limits its efficacy. Essay Nig Our! Thus, the only patients with ovarian cancer who would.
likely benefit would be those with very small residual tumor volumes. Overall, approximately 30 to 40% of patients with small volume residual ovarian cancer have. been shown to demonstrate an objective clinical response to cisplatin-based locally. administered therapy with 20 to 30% of patients achieving a surgically documented. complete response. As a general rule, patients whose tumors have demonstrated an. inherent resistance to cisplatin following systemic therapy are not considered for. treatment with platinum-based intraperitoneal therapy (Altchek, 444-446).
In patients with small volume residual disease at motivation the time of second look laparotomy, who have demonstrated inherent resistance to platinum-based regimens, alternative. intraperitoneal treatment programs can be considered. Other agents include. mitoxantrone, and essay nig our, recombinant alpha-interpheron. A Day Without Math Essay! Intraperitoneal mitoxanthone has. been shown to have definite activity in small volume residual platinum-refractory ovarian.
cancer. Unfortunately, the dose limiting toxicity of the agent is abdominal pain and. adhesion formation, possibly leading to bowel obstruction. Recent data suggests the. local toxicity of mitoxanthone can be decreased considerably by delivering the nig our agent in. Ovarian tumors may have either intrinsic or acquired drug resistance. Many. mechanisms of drug resistance have been described. Expression of the MDR1 gene that.
encodes the drug efflux protein known as p-glycoprotein, has been shown to confer the. characteristic multi-drug resistance to clones of some cancers. The most widely. considered definition of platinum response is response to romeo luhrmann first-line platinum treatment. and disease free interval.
Primary platinum resistance may be defined as any progression. on treatment. Secondary platinum resistance is the absence of progression on primary. platinum-based therapy but progression at the time of essay nig our, platinum retreatment for relapse. Second-line chemotherapy for alternative rock recurrent ovarian cancer is dependent on preferences of. both the patient and physician.
Retreatment with platinum therapy appears to offer. significant opportunity for clinical response and palliation but relatively little hope for. long-term cure. Paclitaxel (trade name: Taxol), a prototype of the taxanes, is cytotoxic. to ovarian cancer. Approximately 20% of platinum failures respond to essay standard doses of. paclitaxel. Service Anchorage! Studies are in progress of nig our, dose intensification and intraperitoneal. administration (Barber, 227-228).
This class of essay motivation, drugs is nig our, now thought to represent an. active addition to the platinum analogs, either as primary therapy, in combination with. platinum, or as salvage therapy after failure of competitive intelligence cover, platinum. In advanced stages, there is suggestive evidence of partial responsiveness of OCCA to. radiation as well as cchemotherapy, adriamycin, cytoxan, and cisPlatinum-containing.
combinations (Yoonessi, 295). Nig Our! Radiation techniques include intraperitoneal radioactive. gold or chromium phosphate and external beam therapy to the abdomen and pelvis. The. role of radiation therapy in intelligence analyst letter, treatment of ovarian canver has diminished in prominence as.
the spread pattern of ovarian cancer and the normal tissue bed involved in the treatment. of this neoplasm make effective radiation therapy difficult. When the essay residual disease. after laparotomy is bulky, radiation therapy is particularly ineffective. Intelligence Analyst Cover Letter! If postoperative. radiation is prescribed for a patient, it is essay, important that theentire abdomen and pelvis are. optimally treated to elicit a response from the tumor (Sharp, 278-280).
In the last few decades, the aggressive attempt to optimize the treatment of. ovarian clear cell adenocarcinoma and ovarian cancer in general has seen remarkable. improvements in the response rates of patients with advanced stage cancer without. dramatically improving long-term survival. The promises of new drugs with activity. when platinum agents fail is encouraging and fosters hope that, in essay, the decades to come, the endeavors of surgical and pharmacoogical research will make ovarian cancer an. easily treatable disease. Altchek, A., Deligdisch, L. (1996). Diagnosis and Management of Ovarian Disorders. New York: Igaku Shoin. Barber, H. (1993).
Ovarian Carcinoma: Etiology, Diagnosis, and Treatment. New York: Coppleson, M. (Ed.). (1981). Gynecologic Oncology (vol. Nig Our! 2). New York: Churchill. Current Clinical Trials Oncology. (1996). Green Brook, NJ: Pyros Education. De La Cuesta, R., Eichorn, J. (1996). Histologic transformation of alternative rock essays, benign.
endometriosis to early epithelial ovarian cancer. Gynecologic Oncology, 60, 238- Disaia, P, Creasman, W. (1989). Clinical Gynecologic Oncology (3rd ed.). St. Louis:
Jenison, E., Montag, A., Griffiths, T. (1989). clear cell adenocarcinoma of the ovary: a clinical analysis and comparison with serous carcinoma. Gynecologic Oncology, Kennedy, A., Biscotti, C. (1993). Histologic correlates of progression-free interval and. survival in essay nig our, ovarian clear cell adenocarcinoma. Gynecologic Oncology, 50, 334-338. Kennedy, A., Biscotti, C. By Baz Luhrmann! (1989). Ovarian clear cell adenocarcinoma.
Gynecologic. Oncology, 32, 342-349. O'Brien, M., Schofield, J., Tan, S. Nig Our! (1993). Essay Prompts! Clear cell epithelial ovarian cancer: Bad. prognosis only in early stages. Gynecologic Oncology, 49, 250-254. O'Donnell, M, Al-Nafussi, A. (1995). Intracytoplasmic lumina and mucinous inclusions. in ovarian carcinoma. Histopathology, 26, 181-184.
Piver, S. Nig Our! (Ed.). (1987). Competitive Intelligence Analyst Cover Letter! Ovarian Malignancies. New York: Churchill Livingstone. Sharp, F., Mason, P., Blackett, T., Berek, J. Nig Our! (1995). Ovarian Cancer 3. New York: Chapman Hall Medical. Yamada, K., Kiyoshi, O. (1995). Monoclonal antibody, Mab 12C3, is a sensitive.
immunohistochemical marker of early malignant change in epithelial ovarian tumors. Anatomic Pathology, 103, 288-294. Yoonessi, M., Weldon, D., Sateesh, S. (1984). Clear cell ovarian carcinoma. Journal.
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Why Is Microsoft Ceo Steve Ballmer Stepping Down? Why is Microsoft CEO Steve Ballmer stepping down? | Strategic Management BUS4040 Assignment 1 | Two months ago (August 23, 2013), there was an announcement from Steve Ballmer, the CEO of Microsoft, declared that he would retire in nig our, the next 12 months, which had attracted much public attention because of its sudden. It was neither planned nor as smooth as portrayed. The interview with many people inside and outside the competitive intelligence company indicate that Ballmer had not aimed to leave this soon and essay, especially after the recent restructuring of the company that he had intensely planned. However, Ballmer’s timeline had been moved up drastically. The nine-member board, including his longtime partner and Microsoft co-founder and chairman Bill Gates all agreed that it was best if he left sooner than later.
It seems that it was due to essay a number of increasingly problematic issues on the immediate horizon, including a potentially nasty proxy fight, continued business performance declines, and Ballmer’s leadership was becoming a very obvious problem. In this report, I will analyze this issue by the following aspects, which includes the background of Steve Ballmer, the development of Microsoft these years and nig our, current situation about the company. Ballmer, 57, who came to Microsoft in 1980 as its first business manager, was the first CEO after founder Bill Gates left the romeo and juliet luhrmann essays post in essay, 2000. Steve Ballmer was born in Detroit, and he grew up in the community of Farmington Hills, Michigan. Essay Workplace? In 1977, he graduated from Harvard University with an essay, A.B. in applied mathematics and economics. Steve Ballmer joined Microsoft in 1980, the romeo first business manager hired by Bill Gates. During college, Ballmer had outstanding performance. He managed the football team, worked on essay nig our, The Harvard Crimson newspaper as.
. can always look at the old invoice’s to check how the invoice should be made. After creating the New Monthly invoice’s the essay workplace invoices should be sent out nig our, as follow. 1. Miklos/Lynx Scan the motivation workplace Invoice send as a PDF File. Then email to Cheryl White CC the email to Ray 2. Jumar/Lowe’s Scan the nig our Invoice send as a PDF File. A Day Essay? Then Email To 'Kevin Tate' CC the email to Ray, Don Pooley, 'Vanessa Trueman' 3. GDIT General Dynamics Scan the essay Invoice Send as a PDF File. Workplace? Then Email To 'Tetterton, Susan' CC the essay email to Ray 4. Pragmatics Fax the rock essays invoice. Essay Nig Our? Look in Microsoft word for competitive cover, Fax cover sheet. the Fax # 1-703-761-4089, To Accounts Payable, Company: Pragmatics. Then Attach the Fax Verification report to invoice. 5. BPS Business Performance Systems Scan the nig our Invoice send as a PDF File. then email to David Isaac CC to Ray 6. Essay? SRA US Marshalls Doesn’t get sent out, the invoice is for are records.
Bi Weekly Billing The Only Bi Weekly Billing is essay, For Project SAIC (SAIC-DHS-EA-FAS) After Creating the romeo and juliet luhrmann essays Invoice for SAIC, Scan The Invoice Send as a PDF File. Then Email To 'Porcaro, Stacey W.' CC the email to Ray, Dittmar Cynthia C, Bailey, Patricia E.' Weekly Billing There are three projects that are billed every week. 1. Lockheed Martin (CLOCS) After putting the essay nig our time expenses into VIP for Don Langguth print out reports from Journyx, VIP, QuickBooks then give. Words: 2910 - Pages: 12. . up your options and join the Peace Corps? The target of alternative rock his outburst then had to defend the proposal in detail until, hopefully, Gates was fully convinced. When subordinates appeared to be procrastinating, he was known to remark sarcastically, I'll do it over the weekend. Gates's role at essay, Microsoft for most of its history was primarily a management and executive role. However, he was an active software developer in the early years, particularly on the company's programming language products. He has not officially been on a development team since working on the TRS-80 Model 100, but wrote code as late as 1989 that shipped in the company's products. On June 15, 2006, Gates announced that he would transition out of his day-to-day role over the next two years to dedicate more time to philanthropy. He divided his responsibilities between two successors, placing Ray Ozzie in charge of day-to-day management and Craig Mundie in charge of long-term product strategy. Control is basic to Gates's nature and his management practice. He has an competitive intelligence cover letter, obsession with detail and with checking up (he even used to sign expenses for his right-hand man, Steve Ballmer). The obsession is so well-known that few believed Gates's evidence in essay, the Microsoft anti-trust trial.
For astonishing example, when asked if he had ever read the complaint in a day essay, the case, Gates said no. But did he know if the complaint made any allegations about a meeting between Microsoft and Netscape. Words: 1975 - Pages: 8. . ------------------------------------------------- Microsoft Office Microsoft Office is an office suite of desktop applications, servers and services for the Microsoft Windows and OS X operating systems, introduced by essay, Microsoft on rock, August 1, 1989. Initially a marketing term for a bundled set of applications, the first version of Office contained Microsoft Word, Microsoft Excel, and Microsoft PowerPoint. Essay Nig Our? Over the years, Office applications have grown substantially closer with shared features such as a common spell checker, OLE data integration and Microsoft Visual Basic for Applicationsscripting language. Microsoft also positions Office as a development platform for romeo essays, line-of-business software under the Office Business Applications brand. Office is reported to nig our now be used by over a billion people worldwide. ------------------------------------------------- Components Desktop applications Word Microsoft Word is alternative, a word processor and was previously considered the main program in Office.
Its proprietary DOC format is considered a de factostandard, although Word 2007 can also use a new XML-based, Microsoft Office-optimized format called .DOCX, which has been standardized by Ecma International as Office Open XML and its SP2 update supports PDF and a limited ODF. Word is essay, also available in some editions of Microsoft Works. It is available for the Windows and OS X platforms. The first version of Word, released in the autumn of. Words: 497 - Pages: 2. . starts connecting it to her laptop’s internal, wired NIC and romeo and juliet luhrmann, explaining the steps. 1. What type of network is Kim trying to connect to? a. WAN b. Nig Our? LAN c. Competitive Intelligence Analyst? PAN 2. Nig Our? To verify that Kim’s NIC (network interface card) works, Michael pings 127.0.0.1, which is known as the: a. loopback address b. dynamic address c. static address When troubleshooting network connections, use ping and ipcon?g. 3. A NIC is to writing service anchorage a LAN as: a. lyrics are to a song b. a key is to a door c. a movie is to a TV Understand local area networks (LANs) 7 Answers 1. Kim is trying to essay nig our connect to the school’s: b. LAN. A LAN is a Local Area Network. Culture Essay Prompts? 2. Essay? To test Kim’s NIC Michael pings the: a. loopback address. The loopback address is 127.0.0.1 and a successful ping verifies that the without math NIC works.
3. A NIC is to a LAN as: b. a key is to a door. A key provides access through a door just as a computer is required to essay nig our have a NIC to access a LAN. Essential details • LANs connect local computers together in a small geographical area. • Perimeter networks provide an extra layer of security for a company’s internal network. • Computers connect to a LAN through a NIC (network interface card). • The loopback address is a reserved, static address of 127.0.0.1. • In Microsoft Windows® 7, right-click Network and romeo and juliet luhrmann, select Properties to view your network configuration. FAST TR ACK HELP • http://windows.microsoft.com/en-US/windows7/ Why-can-t-I-connect-to-a-network • http://support.microsoft.com/kb. Words: 12317 - Pages: 50. . In the late 1990s, Microsoft became so inconceivably rich and mighty that the U.S. government hauled the company into court and essay, threatened to alternative rock break it up over anti-trust violations.
Microsoft agreed to end its unlawful monopolistic practices after the essay Department of Justice charged that the company used one-sided contracts that stifled competition and maintained its monopoly position. Microsoft was accused of constructing a barrier of exclusionary and prompts, excessively limiting licensing agreements to prevent others an opening to develop and market competing products. The Department charged that Microsoft used the following unfair practices: * Exclusionary Per Processor Licenses * Unreasonably Long Licenses * Restrictive Non-Disclosure Agreements The settlement ends these exercises and will help to correct the effects of Microsoft's past illegal behavior, is effective immediately and will be in effect for six and a half years. Since 1988, Microsoft's share of the market has never dropped below 70 percent. However, Microsoft's loss of control has long been evident. The stock is still exchanging at nig our, about half the level it reached at the height of the tech boom 13 years ago. The change in personal computing device adoption has drastically weakened the rule of the Windows operating system platform. As recently as three years ago, Microsoft's Windows was still completely dominant—the platform ran 70% of personal computing devices.
Now, thanks to and juliet the rise of Google's. Words: 312 - Pages: 2. . Essay Outline: Introductory Paragraph: * Topic Sentence: One of the most debated topics in Canada’s relatively short existence is essay, whether this country lacks a concrete national identity. * Briefly defining “National Identity”: A nation’s identity primarily consists of “common points” which the majority of citizens within that specific country can relate with * Point #1: the and juliet two cultures (the English and the French) that help create the foundation of essay nig our this nation have been involved in a day without math essay, a conflict with each other though out the history of the country. * Events such as the 1837 Rebellion, the Quiet Revolution and the late 20th century referendums all prove the negative tension between the 2 dominant cultures of Canada. * Point #2: the multiculturalism Canada is known for turns out to be one of the essay nig our primary reasons why Canada hasn’t yet developed a strong national identity. * Thesis Statement: The combination of resume writing service anchorage Canada’s cultural roots failing to coexist through its history and the significant amount of multiculturalism this country possesses makes it impossible for essay nig our, Canada to have one true national identity. * Closing sentence: the effects of these factors shows today, as the majority of people both inside and outside of Canada fail to recognize a consensual concept within the country, that could be concretely characterized as Canada’s national identity. Essay Prompts? Body Paragraph #1: * Topic Sentence: Perhaps one of the most critical reasons why. Words: 1262 - Pages: 6. . edged up 2% to $16.63bn, as sales of software for essay nig our, corporate computer servers helped offset an romeo and juliet, 8% drop in revenue for essay nig our, PC software.
The results missed Wall Street's forecast for earnings of motivation 49c a share on sales of nig our $17.08bn. Microsoft said the job cuts would reduce operating costs by $1.5bn as it prepares for lower revenue and earnings in culture, the second half of the year. Essay? While we are not immune to essay workplace the effects of the economy, I am confident in the strength of our product portfolio and soundness of our approach, said Steve Ballmer, the Microsoft CEO, in a statement. Microsoft redundancies will include UK jobs Kat Baker Wednesday 06 May 2009 10:52 Microsoft has confirmed up to 150 UK jobs will be among the 5,000 positions lost globally as the software giant reduces its workforce by 5%. A spokesman for essay, Microsoft told Personnel Today it was too early to essay say which areas of the UK workforce would be affected, but he could not rule out cuts in back-office functions, including HR. The redundancies – the first in the company's 34-year history – will reduce its 2,880-strong UK workforce by 5%, and essay nig our, will take effect by June 2010.
The Microsoft UK spokesman said: As part of the plan we announced in January to resume writing service anchorage reduce costs and increase efficiencies, today Microsoft is commencing consultation to remove additional positions across several areas of the company. A number of UK positions are affected, representing about 5% of the 2,880 people currently based in the UK. We are. Words: 1515 - Pages: 7. Why Is Microsoft Ceo Steve Ballmer Stepping Down? . | Why is Microsoft CEO Steve Ballmer stepping down? | Strategic Management BUS4040 Assignment 1 | | | ??10302001432013/10/15 | | Introduction Two months ago (August 23, 2013), there was an essay, announcement from Steve Ballmer, the CEO of Microsoft, declared that he would retire in the next 12 months, which had attracted much public attention because of rock essays its sudden.
It was neither planned nor as smooth as portrayed. Nig Our? The interview with many people inside and outside the company indicate that Ballmer had not aimed to leave this soon and especially after the recent restructuring of the company that he had intensely planned. However, Ballmer’s timeline had been moved up drastically. The nine-member board, including his longtime partner and Microsoft co-founder and a day without essay, chairman Bill Gates all agreed that it was best if he left sooner than later. Essay? It seems that it was due to a number of increasingly problematic issues on the immediate horizon, including a potentially nasty proxy fight, continued business performance declines, and Ballmer’s leadership was becoming a very obvious problem. Romeo And Juliet By Baz Luhrmann Essays? In this report, I will analyze this issue by nig our, the following aspects, which includes the writing anchorage background of essay nig our Steve Ballmer, the rock essays development of Microsoft these years and current situation about the company. Essay Nig Our? Background of service Steve Ballmer Ballmer, 57, who came to Microsoft in 1980 as its first business manager, was the first CEO after founder Bill Gates left the essay nig our post in 2000.
Steve. Words: 1713 - Pages: 7. . Microsoft dominates the operating system market for microcomputers with its Windows operating system. Discuss the culture essay pros and cons this creates for nig our, computer users. Does the dominance of Windows make it easier or harder for you to alternative rock essays use computers? I have only used Windows operating system on all my computers, therefore I am not familiar with any other operating systems. I would think because Microsoft dominates, that if you used a different operating system, it would be more difficult to essay find software with the system requirements to be compatible. Therefore, the opposite would be true if you used the Windows operating system, you could find more compatible software.1. Microsoft dominates the operating system market for microcomputers with its Windows operating system. Alternative Rock Essays? Discuss the pros and cons this creates for computer users. Does the dominance of Windows make it easier or harder for you to use computers?
The pros to nig our the dominate Microsoft operating system is that most people that we come into contact with and discuss computers with will be using the same operating system as you. You will not have to explain how it works (simple tasks) and explaining to someone how to do something will be easier. The other big Pro is that as you upgrade or replace you computer, the worst problem you will encounter (with an operating system) is the newer version, i.e. window XP vs. Alternative Rock? Vista. from computer to computer they are basicly the same. I have found it quite helpfull when I go work on a. Words: 837 - Pages: 4. . William (Bill) H. Gates is chairman of Microsoft Corporation, the worldwide leader in software, services and solutions that help people and businesses realize their full potential. Essay? On June 27, 2008, Gates transitioned out of a day-to-day role in alternative rock essays, the company to spend more time on his global health and education work at essay nig our, the Bill Melinda Gates Foundation. He shares his thoughts about the foundation and other topics on Gates Notes, a Web site launched in January 2010. Gates continues to serve as Microsoft's chairman and essay, as an advisor on key development projects. In June 2006, Craig Mundie assumed the new title of chief research and strategy officer at Microsoft and is responsible for the company's research and incubation efforts.
1. Bill Gates’ early life 1.1 Family Born on Oct. 28, 1955, Gates grew up in Seattle with his two sisters. Their father, William H. Gates II, is a Seattle attorney. Their late mother, Mary Gates, was a schoolteacher, University of Washington regent, and chairwoman of essay nig our United Way International. 1.2 Education Gates attended public elementary school and the private Lakeside School. There, he discovered his interest in culture essay prompts, software and began programming computers at essay, age 13. In 1973, Gates entered Harvard University as a freshman, where he lived down the hall from Steve Ballmer, now Microsoft's chief executive officer.
While at Harvard, Gates developed a version of the programming language BASIC for the first microcomputer - the MITS Altair. 1.3. Words: 7316 - Pages: 30. . employees along functional lines between the Windows operating system companies and the Applications company would presumably follow the workplace existing business units and be relatively straightforward. Dividing the essay operating system employees among the three Windows companies in resume writing service anchorage, an equitable manner might be more difficult. Assuming it has the essay nig our right incentives, Microsoft is in the best position to determine how best to create equivalent groups of employees. One promising method would be to choose “team leaders” and let them sequentially choose employees. Another method would follow the “divide-and-choose” or “cake-cutting” model, in which the person responsible for dividing a unit into equal pieces chooses his piece last. Math Essay? For example, Steve Ballmer could divide up Microsoft’s employees into groups, but the company in which he retains a financial interest would get the last choice of the essay nig our groups. Competitive Letter? This would provide an nig our, incentive to essay motivation workplace create equivalent groups of employees.
With Windows 2000 scheduled for release in February 2000, the division of Windows employees into three groups would come at a good time. Nig Our? Current staffing levels for the initial release — some 4800 developers — will not be needed going forward. Alternative Rock Essays? Many of these developers would have to be released or shifted to other projects. The availability of nig our these additional developers makes it easier to staff three competing Windows companies without having to cover hire additional employees. Indeed, the creation of three. Words: 15664 - Pages: 63. . Performance | Benefits | Drawbacks | Personal Observations | * Get firsthand knowledge * Information isn’t filtered * Intensive coverage of work activities | * Subject to personal biases * Time-consuming * Obtrusive | Statistical Reports | * Easy to essay visualize * Effective for showing relationships | * Provide limited information * Ignore subjective factors | Oral Reports | * Fast way to get information * Allow for verbal and nonverbal feedback | * Information is filtered * Information can’t be documented | Written Reports | * Comprehensive * Formal * Easy to file and retrieve | * Take more time to prepare | What We Measure What is motivation workplace, measured is probably more critical to the control process than how it’s measured.
Why? Because selecting the wrong criteria can create serious problems. Essay? Besides, what is measured often determines what employees will do.8 What control criteria might managers use? Some control criteria can be used for any management situation. For instance, all managers deal with people, so criteria such as employee satisfaction or turnover and service, absenteeism rates can be measured. Keeping costs within budget is also a fairly common control measure. Other control criteria should recognize the different activities that managers supervise.
For instance, a manager at a pizza delivery location might use measures such as number of pizzas delivered per essay day, average delivery time, or number of coupons redeemed. A. Words: 1214 - Pages: 5. . the Mark: Five Reasons Why Target Failed in Canada. The Globe and Mail. January 15, 2015.
Accessed January 15, 2015. http://www.theglobeandmail.com/report-on-business/missing-the-mark-5-reasons-why-target-failed-in-canad/article22459819/. Canadians along the border find it cheaper to buy Target products across the broder. Citation: Peterson, Hayley. Romeo And Juliet Essays? 5 Reasons Target Failed In Canada. Business Insider. January 15, 2015. Accessed January 15, 2015. http://www.businessinsider.com/why-target-canada-failed-2015-1#ixzz3R5fwxqzJ. Business management have many responsibilities, they can single handily lead to the business's success and failure. Nig Our? Target Canada's management is an essay, example of how bad managing can lead to a business's failure. Target Canada's management faced a number of problems when they tried to essay nig our launch in Canada and because the a day management was not able to make good decisions, it lead to Target Canada having to close all of their stores in Canada.
Some of the bad decisions that Target Canada's management team made were. Words: 374 - Pages: 2. . Steve Sakar CRJ 303 9/27/2015 Hans Rosling presented a powerful presentation on essay nig our, our societies old mindset of social classes, as well as, the overall meaning of “we” and “them”. Rosling started off the TED talk by alternative rock essays, introducing how his students talked about the essay difference between “we” and “them”. Romeo By Baz? The students classified the “we”, as the essay Western World, and the “them” as the Developing world.
Our old mindset about the Western world, was the western countries consisted of small families who lived long lives. Furthermore, our mindset on the developing world, was the third world countries consisted of larger families who lived short lives. Throughout the writing video Rosling presents a variety of data sets about our mindsets. For example, Rosling presents scatterplots about income and health, income and child mortality, as well as, life expectancy per family size. He uses the scatterplots to essay nig our show us, over time that the West is no longer the big super power people once thought the west was. Also, Rosling described we shouldn’t differentiate developing and developed countries based, on family size, income, life expectancy, or health, because their is alternative rock essays, no longer a difference between developing and developed countries, as the third world countries have caught up to the Western countries. The video did end up changing my mindset on the world’s classification of “we” and “them”. Essay Nig Our? I never displayed a deeper knowledge on the outside world, and how the other countries. Words: 575 - Pages: 3. . Microsoft Company Analysis Kevin Roberts Matthew Ponder Joseph Horton Strategic Management Arkansas State University Introduction Microsoft is a company centered around today’s constantly growing and evolving technology field.
From company servers, to Laptops, even tablets and smartphones. Microsoft is expanding its horizons to keep pace with, or even out essay, perform its competitors. Microsoft’s corporate strategy centers around their product being accessible to customers in many different ways. This access based strategy differentiates itself from other companies in the same industry, like IBM, Apple, Google, Oracle, and the like. Essay Nig Our? This industry, that most people would just consider “technology” or “computers”, is divided up into several sectors.
Microsoft obtains most of its profits from the sale of its enterprise software and licenses, making this their primary industry, while secondaries include, but are not limited to, smartphone manufacturing, Nokia, PC manufacturing, the Surface, Gaming, the Xbox 36 and and juliet luhrmann, Xbox One, and other software products. Essay Nig Our? Microsoft is a corporate giant covering many major countries, but no company is essay motivation, completely flawless. They are actually projecting to have reduced profits over the next few years. This along with the software industry moving to essay cloud-based computing, open-source software becoming more popular, Windows mobile devices not taking off as expected, and essay workplace, hacker threats to their Operating Systems, are issues that.
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A Guide for Teens: How to Find a Summer or Part-Time Job. by Randall S. Essay Nig Our. Hansen, Ph.D. Even if summer vacation is still a few months away for most teens, now is the time to plan and lay a foundation for by baz, landing that cool summer job you really want. Some caveats: This article is really geared to older high school and college teens, with a focus on summer jobs, not internships. For younger teens (under 15), please check out another of our articles, Job Ideas for Teens 15 and nig our Younger: Beyond Babysitting. For college students looking for without, internship tips, please read our article, How to Find Your Ideal Internship: A Three-Step Process for Gaining Key Work Experience While in College. The Action Plan for Teens Wanting a Summer Job.
The first step you need to do is decide on nig our, the summer job you want or need #8212; in terms of the type of job, the location, the hours, the writing pay. Essay. You may not be able to find a job that meets all your needs, but given the current employment situation you should strive to find one that meets as many as possible.The second step you need to do is complete a self-analysis. What do you have to offer an employer? What kind of skills do you have? What kind of other work have you done #8212; paid or volunteer? What have you learned at school that might be useful in your ideal summer job?The third step you need to do is develop a resume. You will put forth a very professional image if you present a professional-looking resume to potential employers. You#8217;ll want to visit Quintessential Careers: Resume Resources. You#8217;ll also need to learn about cover letters, so plan on visiting Quintessential Careers: Cover Letter Resources.The fourth step you need to do is use all your available resources to land that ideal summer job.
Talk with your parents and older family members, your friends#8217; parents, your teachers, and any other adults you know and ask them if they have any contacts at your ideal job#8217;s company. Give them copies of your resume. We call this step networking, and it will give you the highest chances of landing your ideal job.The fifth step is hitting the pavement, reading the newspaper want ads, and/or surfing the Web. If you don#8217;t get any job leads from the essay workplace fourth step, you have to take action!The sixth step is applying for essay nig our, the jobs that interest you. This step is where you again use your resume. Make sure you are familiar with job applications and have all the information you need to complete them.The seventh step is interviewing for writing service, the jobs.
Make sure you know something about the company; develop answers to essay nig our, common interview questions; think of a few questions you could ask; practice, practice, practice with a family member of rock, friend; dress conservatively for the interview. You can read these interviewing tips in more detail #8212; and find lots more #8212; by visiting Quintessential Careers: Interviewing Resources. There are any number of places where you can look for a good summer job: Local merchants: local stores often need good help #8212; and essay nig our not just in competitive analyst letter the summer. Small businesses: most towns have a number of essay, small business offices #8212; and culture essay prompts your family or friends probably know several owners or office managers. Corporate offices: many have established summer jobs and internship programs, but often these are the nig our most competitive. Stores at the mall: have a favorite store you like to rock, shop at nig our in the and juliet by baz luhrmann mall?
Maybe now is the time to essay nig our, get a job there #8212; just be careful not to spend all your earnings buying their products. Competitive Analyst Cover Letter. Hotels and nig our resorts: summer is the busy season for most hotels and resorts. Tourist attractions: even if you don#8217;t live in Florida or California, most states have tourist attractions that especially need help during the busy tourism season. Motivation. Golf Tennis clubs: as the weather improves, these clubs are usually looking for part-time help. Grocery stores: maybe not the most exciting jobs, but probably the most convenient #8212; and essay nig our not just for summer. Fast food and restaurants: local restaurants always need good help #8212; and romeo and juliet by baz essays while not the nig our most glamorous, it#8217;s still a job.
Parks and recreation departments: city, state, and national parks and essay prompts recreation departments often develop special summer programs, and thus have job opportunities. Local government summer job programs: often various government agencies sponsor different kinds of summer youth work programs. Nig Our. Summer camps: okay, you went to camp as a kid #8212; now you can go back as a counselor and get paid while being at camp. Working for motivation workplace, yourself: there are all sorts of nig our, jobs/businesses you could develop for yourself in essay prompts your neighborhood #8212; check out my article, Job Ideas for Teens 15 and Younger: Beyond Babysitting. Essay Nig Our. The Web: especially if you want to work outside your neighborhood, or even your state, the Web is the place for you to explore all sorts of summer job opportunities #8212; so go visit Quintessential Careers: Summer Job Websites. What do Employers Look for competitive cover, in Teens. Employers want motivated teens who are going to arrive to essay nig our, work on time, have a positive attitude, work hard, work well with others, show leadership qualities, work their full shift, and do the best job they can. You need to show your employer that you are a good investment, both for the current position, as well as for any potential future positions. Final Words of Advice for Job-Hunting Teens.
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Flags of Our Fathers Essay Questions. Discuss the nig our, role that mothers play for the six flag raisers. Mothers are a theme that links all men in battle: in his comparison of the essays, Japanese, German, and American troops, Bradley points out that they are connected by their dying word, which is invariably, Mother! In the case of the six flag raisers, mothers are also important as religious influences. After the death of her young daughter Mary Ellen, Kathryn Bradley concentrates on essay nig our, raising John devoutly Catholic; Mike Strank's Catholic faith is also the alternative rock essays, result of his mother's influence.
Goldie Sousley and her son, Franklin, are extremely close after the deaths of his brother and father. Belle Block strongly opposes Harlon's joining the football team, but her influence on him in terms of his Seventh-Day Adventist beliefs is clear. Ira Hayes learned what he knew about the Bible from his mother, Nancy, who also made sure he got a good education. Likewise, Rene Gagnon's mother is the most important person in essay nig our his life until he marries Pauline Harnois. After she divorces his father, Irene Gagnon takes Rene to work with her and showers him with attention. Belle Block's role as a mother is especially important. When the 5th Division makes National Service Life Insurance policies available to the Marines, Harlon purchases a ten-thousand-dollar policy with his mother, Belle, as the rock, sole beneficiary. Belle Block is convinced that her son, Harlon, is essay, one of the competitive intelligence analyst cover, men in the famous flag-raising photograph, though everyone else thinks it is impossible to nig our, be sure. After she learns of Harlon's death on Iwo Jima, something in her had been broken. Are the six flag raisers religious? How is religion used to characterize them?
As the flag raisers are introduced in culture prompts Chapter 2, it is clear how religion influences each of the flag raisers in their childhoods. Essay Nig Our? John Bradley and motivation workplace Mike Strank are devout Catholics. Essay? Harlon Block is more influenced by the Seventh-Day Adventist Church than his other siblings are, though he leaves his religious school to play football at romeo by baz essays Welasco High School. Ira Hayes lived just a few steps from the church in essay nig our which his mother was an important figure. Letter writing demonstrates the culture essay prompts, role religion played in the lives of the essay, flag raisers. In Chapter 4, a letter from Ira Hayes to his parents mentions a sermon Alcohol versus Christianity and how it touched him.
When Harlon Block enlisted with his entire football team, Belle Block pleaded with her son to claim conscientious objection as a Seventh-Day Adventist to avoid battle, like his brothers had. Bradley focuses on Harlon's religion when he points out alternative rock essays that, after Harlon landed on Bougainville, Harlon, the Seventh-Day Adventist, was getting his first glimpse of the world's wickedness as he trudged past these remains of friends and enemy dead. After getting married, John and Betty Bradley get in the habit of praying together before bed, and Betty notices that Jack adds on, Blessed Mother, please help us so everything turns out all right, a prayer he had often said on Iwo Jima. How does James Bradley characterize Ira Hayes as both an innocent boy and nig our a man? The tension between boyhood and manhood is a constant theme in this book, especially with relation to Ira. A letter from without Ira Hayes to his parents from training in San Diego is used to show that his boyish innocence did not vanish overnight. Essay? When he returns home on furlough after fighting in Bougainville, the slim, quiet boy had been transformed into cover, a very formidable-looking young man. Essay? his words were typically thoughtful and gentle, but they were no longer the alternative rock essays, words of a boy. A man was talking now, a man who had seen things. Nig Our? In Chapter 5, Ira writes home to rock essays, his parents, Don't worry about me. Essay? I'm a man now, no young guy. However, according to anecdotes from those who trained with him at this time, his behavior was erratic and he was often depressed.
The theme of the tension between boyhood and manhood reappears in the opening sentence of Chapter 18: They were no longer boys now; they were postwar men. Intelligence Analyst Letter? This line implies that the flag raisers now have assumed a level of responsibility for their lives that they didn't have before. Ira Hayes is offered help (whatever the motivation) from the Chicago Sun-Times and essay from Elizabeth Martin, but is unable to pull his life together. In a letter home to competitive intelligence, his parents, he writes, So I was cured in their eyes. They had done their part. Now the real test is essay nig our, up to me. all I need is the will power. Does James Bradley believe that the six flag raisers are heroes? At the end of the book, Bradley admits that after researching their lives, the six flag raisers seem like heroes to him, if not for their role in by baz luhrmann essays raising the flag on Mount Suribachi. However, he adheres to his father's insistence that, The heroes of Iwo Jima are the guys who didn't come back. Heroism is a theme that is often misunderstood or misrepresented by the media, in Bradley's opinion.
One of the essay nig our, main reasons Jack Bradley refuses to talk about his experiences on Iwo Jima, according to James Bradley his son, is that he doesn't want to intelligence, seek fame as a hero. He believes that heroes are heroes because they have risked something to help others. In contrast, the nig our, flag raising contained no action worthy of remembering, and analyst cover letter thus doesn't make him a hero; he is essay nig our, made a hero by his actions in resume writing anchorage saving his fellow Marines and in attempting to save those who ended up dying on nig our, the island. What does the author think about the media's coverage of the flag raising on letter, Iwo Jima and the following events? Give examples. The media's influence becomes a main theme in the book, as the symbol of the flag raising and the flag raisers themselves are distorted and packaged by the media in ways that will serve the interests of the government, but that are not necessarily reflective of the truth. Here, John Daly of the NBC Red declares that the essay nig our, Japanese had attacked Pearl Harbor by air, and resume service Americans are described as poring over their newspapers to learn more about Japan, their new enemy. The photos published in Life magazine in essay 1938 of intelligence, Japanese atrocities at Nanking sowed terror not only in nig our the American public, but also in the Marines who arrived at Guadalcanal. After the devastating battle at Tarawa, Bradley recounts how newspaper editorials announced, This Must Not Happen Again! alongside pictures of dead Marines floating in essay motivation the ocean around the island. The theme of the essay, misguided media is extremely relevant as newspapers largely ignore the raging battle on Iwo Jima, since it does not adhere to their fake story of a day math, valor climbing Mount Suribachi. Bradley addresses the members of the press with a degree of disdain, sarcastically referring to them as gentlemen of the press in nig our contrast to the soldiers fighting the battle.
Time magazine propagates an workplace, unverified rumor on its radio program when it broadcasts that the photograph was staged. Nig Our? Rosenthal demands and luhrmann essays receives a public apology from Time, but the photograph would cause him much frustration in the future. Though the Marines continue to fight on essay, Iwo Jima, the March 5 edition of Time magazine published the a day without essay, photograph of the flag raising on its front page as if the nig our, battle had been won. Jack Bradley is mistrustful of the media and refuses to give interviews to the journalists who often call his home for the rest of his life. Anchorage? The media is also targeted as contributing to Ira Haye's destructive behavior. Essay? Bradley claims, The more helpless and vulnerable Ira grew, the more brazen was the press's exploitation of him.
A reporter from the Chicago Sun-Times visits him in math jail and takes his photograph, and that newspaper posts his bail and enrolls him in a rehabilitation program. They promote fixing his life as their sanctimonious mission, but in essay nig our the process, they put pressure on him that contributes to his demise. How does James Bradley's view of the resume writing anchorage, Japanese government during World War II differ from his characterization of individual Japanese soldiers? The theme of essay nig our, individuals versus country is introduced with respect to Japan as Bradley describes the atmosphere leading up to World War II for that country. Throughout the 1930s, Japan, as a country led by a military regime, conquered Manchuria and China. Alternative Rock? Though the Japanese army employed ruthless tactics, the citizens themselves are described as being squeezed in an iron vise, totally brainwashed and manipulated into carrying out the nig our, will of the essays, government. In relating the atrocities committed by the Japanese soldiers at Nanking, the capital of China, Bradley distinguishes the Japanese from the Germans, the Americans' other enemy in World War II. The sense of essay nig our, restraint that dictated even the most brutal front in Europe was absent from the war in the Pacific.
Japanese soldiers believed they were fighting in the Way of the Warrior, or the Bushido tradition, but in fact they were being forced to operate within a twisted version of this warrior ideal; the essay workplace, Japanese military in the 20th century was more of a cult of essay nig our, death, and its warriors were viewed as expendable. During the intelligence letter, air raid in Chapter 9, an American on board a ship offshore of Iwo Jima reports that he could see the face of the nig our, Japanese pilot. You could see the romeo and juliet by baz luhrmann, fear of death on his face. This type of description humanizes the Japanese kamikaze fighters as real people with real fear. Likewise, as Bradley tells of the soldiers ordered by Colonel Kanehiko Atsuchi to abandon Mount Suribachi, their plight is unfortunate at the hands of the Japanese navy guard, which punishes them for surrendering. How does the American public's view of the flag raising on Iwo Jima differ from the view of the six flag raisers? The press is responsible for nig our the American peoples' perception of the war, and during the writing anchorage, majority of the battle on Iwo Jima, that perception contrasted with the ideas of the flag raisers themselves. The flag raising had been turned into a symbol of success and victory, a convenient symbol of a 'happy ending.' Attention had now begun to shift away from Iwo Jima, even as the great bulk of the bloodletting began. The contrast between perception and reality is also clear in Bradley's relation of Representative Homer Angell of Oregon's oration in the House of essay nig our, Representatives, in which he declares the photograph to competitive intelligence cover, be a representation of 'the dauntless permanency of the American spirit.' Half a world away, the boys did not look so dauntless.
Later, as described in Chapter 14, Jack Bradley is mistrustful of the media and refuses to give interviews to the journalists who often call his home for the rest of his life. Give examples of rhetorical techniques used often by James Bradley in Flags of Our Fathers. Bradley often uses short, emphatic sentences or sentence fragments, rhetorical questions, and direct address. For example, at the conclusion of Chapter 5, he writes, December 1944. The last Christmas for too many young boys. Then off for the forty-day sail to Iwo Jima. In Chapter 6, describing the upcoming battle: The boys would have only their buddies to essay nig our, depend upon, buddies who were willing to alternative, die for one another. As soon they would. Essay Nig Our? Finally, these techniques appear in a letter in the final chapter of the without math essay, book from his daughter, Alison, to her deceased grandfather, John Bradley, where she asks him why he kept so silent about his war experience.
Other than narrative, what tools does Bradley use to nig our, tell the stories of the without math, six flag raisers? In gathering evidence for this book, James Bradley relied heavily on essay nig our, anecdotes, interviews, and letters from those who served with the six flag raisers. The letters with descriptions of the flag raisers are often used as characterization tools, demonstrating others' opinions of the men. For example, in Chapter 5, Bradley quotes a letter from one Joe Rodriguez, who reported to Mike Strank, to demonstrate how Mike was the quintessential Marine: He was a born leader, a natural leader, and a leader by example. He had real concern for analyst cover letter us, he was a big brother to us. Likewise, a letter from one Kenneth Milstead characterizes Ira: Ira was always depressed. Bradley also uses the technique of direct address, especially in the last chapters.
In explaining why he felt such an immediate bond with Rene Gagnon, Jr., he tells the reader, Imagine six boys from your youth. Line them up in your mind. They are eighteen to twenty-four years old. Select them now; see them. How many marriages, how many children will intersect their lives? These rhetorical questions are used again when Bradley refutes reporter Mary Elson's analysis of his father's comment about the fact that there happened to be a flag attached to the pole he put in the ground: Odd? Irrelevant? A casual afterthought? I don't think so. How does Bradley characterize America during World War II and immediately following? The six flag raisers are all raised in small towns, and Bradley describes them as representative of the hard-working families that made up the core of America at essay that time.
He says that the Antigo Daily Journal got it right in describing his father's quiet, modest nature and philanthropic efforts as an example of the best of cover letter, small-town American values. These values include support for soldiers fighting abroad, in Europe and in the Pacific, and are manifested by donations to the bond tours. A Treasury Department source is quoted as nostalgically relating that, We were one then, implying that the country united in support of their young men in a way it would no longer do. How To Cite http://www.gradesaver.com/flags-of-our-fathers/study-guide/essay-questions in MLA Format. Study Guide Navigation About Flags of Our Fathers Flags of Our Fathers Summary Character List Glossary Themes Quotes and Analysis Summary And Analysis Chapters 1 and 2 Chapters 3 and 4 Chapters 5, 6, and 7 Chapters 8, 9, and 10 Chapters 11 and 12 Chapters 13 and 14 Chapters 15 and 16 Chapters 17 and 18 Chapters 19 and 20 Flags of Our Fathers and Letters from Iwo Jima: The Movies Related Links Essay Questions Quizzes - Test Yourself! Quiz 1 Quiz 2 Quiz 3 Quiz 4 Citations Related Content Study Guide Q A Mini-Store James Bradley Biography. Flags of essay nig our, Our Fathers Questions and Answers. The Question and Answer section for Flags of Our Fathers is a great resource to ask questions, find answers, and discuss the novel. In the nation's memory, the rock essays, flagraisers' transforation from individuals to anonymous representative figures had begun. The true heroes of Iwo Jima were the ones who didn't come back. I think the answer is nig our, summed up in his belief that the true heroes of writing anchorage, Iwo Jima were the ones who didn't come back.
People follow the media. People, in a democracy, elect governments. I would say the media is the strongest. Study Guide for Flags of Our Fathers. Flags of Our Fathers study guide contains a biography of James Bradley, literature essays, quiz questions, major themes, characters, and a full summary and analysis.